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NEJM-CPC Case Studies

The New England Journal of Medicine [NEJM] publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference [CPC] series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital [MGH].

Using the clinical features of these cases you can evaluate your own diagnostic skills, compare and calibrate your diagnostic performance to that of the physicians at MGH. If you are registered with Isabel, you can use the DDx Generator and expand the list of likely suspects. Click through to the synoptic and/or detailed diagnosis specific and up to date knowledge from Isabel's database of textbooks and journals.

How Good A Diagnostician Are You? What is your differential diagnosis for these NEJM CPC Cases?

  • Click on each case below and you will find clinical features of the case extracted by our team.
  • Alternatively, if you have full-text access to NEJM, you can use the link in the document, read the case presentation and extract the clinical features yourself.
  • Before you get the differential diagnosis of each case, why not construct a complete differential diagnosis yourself and compare and calibrate your performance to that of the experts at Massachusetts General Hospital [MGH].
  • How often did you consider the final diagnosis of the case?
  • You will also be able to evaluate Isabel's differential diagnosis results - in screen shots.
  • Compare your performance to that of Isabel's output.
  • If you are registered with Isabel, you can also cut & paste the extracted clinical features into Isabel and let the DDx Generator jog your memory with a list of likely suspects !

How Does Isabel Perform? Does isabel suggest the final diagnosis on these challenging CPC Cases?

  • Click on each case below and you will find the clinical features extracted by our team.
  • See how Isabel performs on these diagnostically challenging cases.
  • The analysis of Isabel's performance includes :
  • Does Isabel suggest the final diagnosis of the case?

  • How many of the MGH differential diagnoses does Isabel suggest?

  • How well does Isabel perform when clinical features are extracted [negation avoided & numerical values interpreted]?

  • How well does Isabel perform when you 'cut & paste' the entire presentation into Isabel's query box?

2016 NEJM CPC Cases

      Jan 14 1 An 18-Year-Old Man with Fever, Abdominal Pain, and Thrombocytopenia

2015 NEJM CPC Cases

      Jan 16 1 A 25-Year-Old Man with Abdominal Pain, Syncope, and Hypotension

2014 NEJM CPC Cases

      Jan 9 1 A 32-Year-Old Man with Loss of Vision and a Rash

2013 NEJM CPC Cases

      Sep 19 29 A 32-Year-Old HIV-Positive African Man with Dyspnea and Skin Lesions
      Sep 12 28 A 52-Year-Old Man with Cardiac Arrest after an Acute Myocardial Infarction
      Aug 29 27 A 6.5-Month-Old Boy with Fever, Rash, and Cytopenias
      Aug 22 26 A 46-Year-Old Woman with Muscle Pain and Swelling
      Aug 15 25 A 71-Year-Old Man with Hematuria and a Mass in the Bladder
      Aug 08 24 A 53-Year-Old Woman with Erythroderma, Pruritus, and Lymphadenopathy
      Jul 25 23 A 54-Year-Old Woman with Abdominal Pain, Vomiting, and Confusion
      Jul 18 22 A 51-Year-Old Woman with Epistaxis and Oral Mucosal Ulcers
      Jul 11 21 A 68-Year-Old Man with Metastatic Melanoma
      Jun 27 20 A 29-Year-Old Man with Anemia and Jaundice
      Jun 20 19 A 35-Year-Old Woman with Recurrent Goiter and Ductal Carcinoma of the Breast
      Jun 13 18 A 32-Year-Old Woman with Recurrent Episodes of Altered Consciousness
      May 30 17 A 56-Year-Old Woman with Poorly Controlled Diabetes Mellitus and Fatigue
      May 23 16 A 12-Year-Old Girl with Irritability, Hypersomnia, and Somatic Symptoms
      May 16 15 A 76-Year-Old Man with Fever, Worsening Renal Function, and Altered Mental Status
      May 09 14 A 70-Year-Old Woman with Vaginal Bleeding
      Apr 25 13 A 6-Year-Old Girl with Bone and Joint Pain and Abdominal Distention
      Apr 18 12 An 18-Year-Old Woman with Pulmonary Infiltrates and Respiratory Failure
      Apr 11 11 A 4-Year-Old Boy with Fever and Abdominal Pain
      Mar 28 10 A 30-Year-Old Man with Fever, Myalgias, Arthritis and Rash
      Mar 21 9 A 9-Year-Old Boy with Fever, Cough, Respiratory Distress and Chest Pain
      Mar 14 8 A 48-Year-Old Woman with Carcinoma In Situ of the Breast
      Feb 28 7 A 77-Year-Old Woman with Long-Standing Unilateral Thoracic Pain and Incontinence
      Feb 21 6 A 54-Year-Old Man with Recurrent Diarrhea
      Feb 14 5 A 52-Year-Old Woman with a Mass in the Thyroid
      Jan 31 4 A 50-Year-Old Man with Acute Flank Pain
      Jan 24 3 A 72-Year-Old Woman with Abdominal Pain and Distention after Peritoneal
      Jan 17 2 A 20-Year-Old Man with Recurrent Ear Pain, Fever, and Headache
      Jan 10 1 A 63-Year-Old Man with Paresthesias and Difficulty Swallowing

2012 NEJM CPC Cases

      Dec 27 40 A 43-Year-Old Woman with Cardiorespiratory Arrestafter a Cesarean Section
      Dec 20 39 A 55-Year-Old Man with Alcoholism, Recurrent Seizures, and Agitation
      Dec 13 38 A 60-Year-Old Man with Abdominal Pain and Aortic Aneurysms
      Nov 29 37 A 21-Year-Old Man with Fevers, Arthralgias, and Pulmonary Infiltrates
      Nov 22 36 Recovery of a 16-Year-Old Girl from Trauma and Burns after a Car Accident
      Nov 15 35 A 69-Year-Old Chronically Ill Man with Weakness, Anorexia, and Diffuse Pain
      Nov 08 34 A 27-Year-Old Woman in Ethiopia with Severe Pain, Bleeding and Shock during Labor
      Oct 25 33 A 34-Year-Old Woman with Episodic Paresthesias and Altered Mental Status after Childbirth
      Oct 18 32 A 35-Year-Old Man with Respiratory and Renal Failure
      Oct 11 31 An 18-Year-Old Man with Blurred Vision, Dysarthria and Ataxia
      Sep 27 30 A 54-Year-Old Woman with HIV Infection, Dyspnea, and Chest Pain
      Sep 20 29 A 49-Year-Old Man with Pain and Cranial-Nerve Palsies after Treatment of Oral Cancer
      Sep 13 28 A 30-Year-Old Woman with Shock and Abdominal-Wall Necrosis after Cesarean Section
      Aug 30 27 A 60-Year-Old Woman with Painful Muscle Spasms and Hyperreflexia
      Aug 23 26 A 70-Year-Old Woman with Fever and Back Pain
      Aug 16 25 A 15-Year-Old Boy with Abdominal Pain, Hematochezia and Anemia
      Aug 09 24 A 38-Year-Old Man with Abdominal Pain and Altered Mental Status
      Jul 26 23 A 59-Year-Old Man with Abdominal Pain and Weight Loss
      Jul 19 22 A 34-Year-Old Man with Intractable Vomiting after Ingestion of an Unknown Substance
      Jul 12 21 A 27-Year-Old Man with Fatigue, Weakness, Weight Loss and Decreased
      Jun 28 20 A 77-Year-Old Man with Leg Edema, Hematuria and Acute Renal Failure
      Jun 21 19 A Premature Newborn Boy with Respiratory Distress
      Jun 14 18 A 35 Year-Old Man with Neck Pain, Hoarseness, and Dysphagia
      May 31 17 A 54-Year-Old Man with Visual-Field Loss and a Mass in the Brain
      May 24 16 A 32-Year-Old Woman with HER2-Positive Breast Cancer
      May 17 15 A 48-Year-Old Woman with Diplopia, Headaches, and Papilledema
      May 10 14 A 43-Year-Old Woman with Fever and a Generalized Rash
      Apr 26 13 A 62-Year-Old Man with Paresthesias, Weight Loss, Jaundice, and Anemia
      Apr 19 12 A 10-Month-Old Girl with Vomiting and Episodes of Unresponsiveness
      Apr 12 11 A 60-Year-Old Man with Weakness, Rash, and Renal Failure
      Mar 29 10 A 16-Year-Old Boy with Epigastric Pain and a Mediastinal Mass
      Mar 22 9 A 67-Year-Old Man with a Persistently Elevated PSA Level
      Mar 15 8 A 53-Year-Old Man with Crohn's Disease, Diarrhea, Fever, and Bacteremia
      Mar 08 7 A 79-Year-Old Man with Pain and Weakness in the Legs
      Feb 23 6 A 45-Year-Old Man with a History of Alcohol Abuse and Rapid Cognitive Decline
      Feb 16 5 A 39-Year-Old Man with a Recent Diagnosis of HIV Infection and Acute Psychosis
      Feb 09 4 A 37-Year-Old Man with Muscle Pain, Weakness, and Weight Loss
      Jan 26 3 A Newborn Boy with Vomiting, Diarrhea, and Abdominal Distention
      Jan 19 2 A 63-Year-Old Woman with Dyspnea and Rapidly Progressive Respiratory Failure
      Jan 02 1 An 82-Year-Old Man with Persistent Ulcers on the Hands

2011 NEJM CPC Cases

      Dec 29 40 A 52-Year-Old Man with Weakness, Infections, and Enlarged Adrenal Glands
      Dec 22 39 A Woman in Her 90s with Unilateral Ptosis
      Dec 15 38 A 34-Year-Old Man with Diarrhea and Weakness
      Dec 08 37 A 9-Month-Old Boy with Recurrent Tachypnea and Respiratory Distress
      Nov 24 36 A 93-Year-Old Woman with Shortness of Breath and Chest Pain
      Nov 17 35 A 33-Year-Old Woman with Postpartum Leukocytosis and Gram-Positive Bacteremia
      Nov 10 34 A 75-Year-Old Man with Memory Loss and Partial Seizures
      Oct 27 33 A 56-Year-Old Man with Hypophosphatemia
      Oct 20 32 A 19-Year-Old Man with Recurrent Pancreatitis
      Oct 13 31 A 55-Year-Old Man with Oligometastatic Lung Cancer
      Sep 29 30 A 62-Year-Old Woman with Renal Failure
      Sep 22 29 A 66-Year-Old Woman with Cardiac and Renal Failure
      Sep 15 28 A 74-Year-Old Man with Pemphigus Vulgaris and Lung Nodules
      Sep 08 27 A 17-Year-Old Boy with Abdominal Pain and Weight Loss
      Aug 25 26 A 7-Year-Old Boy with a Complex Cyst in the Kidney
      Aug 18 25 A 62-Year-Old Woman with Anemia and Paraspinal Masses
      Aug 11 24 A 36-Year-Old Man with Headache, Memory Loss, and Confusion
      Jul 28 23 A 40-Year-Old Pregnant Woman with Placenta Accreta Who Declined Blood Products
      Jul 21 22 A 79-Year-Old Man with a Rash, Arthritis, and Ocular Erythema
      Jul 14 21 A 31-Year-Old Man with ALK-Positive Adenocarcinoma of the Lung
      Jun 30 20 A 30-Year-Old Man with Diarrhea after a Trip to the Dominican Republic
      Jun 23 19 A 4-Year-Old Haitian Boy with Vomiting and Diarrhea
      Jun 16 18 A 35-Year-Old HIV-Positive Woman with Headache and Altered Mental Status
      Jun 09 17 A 49-Year-Old Woman with a Mass in the Breast and Overlying Skin Changes
      May 26 16 A 67-Year-Old Man with Recurrent Prostate Cancer
      May 19 15 A 19-Year-Old South African Woman with Headache, Fatigue, and Vaginal Discharge
      May 12 14 A Woman with Asymmetric Sensory Loss and Paresthesias
      Apr 28 13 A 49-Year-Old Man with Adenocarcinoma of the Rectum
      Apr 21 12 A 9-Month-Old Boy with Acute Liver Failure
      Apr 14 11 A 47-Year-Old Man with Systemic Lupus Erythematosus and Heart Failure
      Mar 31 10 A Woman with Fever, Confusion, Liver Failure, Anemia, and Thrombocytopenia
      Mar 24 09 A 37-Year-Old Man with Flushing and Hypotension
      Mar 17 08 A 32-Year-Old Woman with Seizures and Cognitive Decline
      Mar 10 07 A 52-Year-Old Man with Upper Respiratory Symptoms and Low Oxygen Saturation Levels
      Feb 24 06 A 77-Year-Old Man with Dyspnea, Weakness, and Diaphoresis
      Feb 17 05 A 65-Year-Old Man with Hematuria after Treatment for Prostate Cancer
      Feb 10 04 A 4-Year-Old Boy with Back Pain and Hypercalcemia
      Jan 27 03 A 58-Year-Old Woman with a Mass in the Liver
      Jan 20 02 A 30-Year-Old Woman with Shock after Treatment of a Furuncle
      Jan 13 01 A 35-Year-Old Man with Fever, Bacteremia, and a Mass in the Left Atrium

2010 NEJM CPC Cases

      Dec 30 40 A 68-Year-Old Woman with Chest Pain during an Airplane Flight
      Dec 23 39 A 19-Year-Old Woman with Nausea, Jaundice, and Pruritus
      Dec 16 38 A 13-Year-Old Girl with an Enlarging Neck Mass
      Dec 09 37 A 16-Year-Old Girl with Confusion, Anemia, and Thrombocytopenia
      Nov 25 36 A 50-Year-Old Woman with Pain and Loss of Hearing in the Left Ear
      Nov 18 35 A 56-Year-Old Man with Cough, Hypoxemia, and Rash
      Nov 11 34 A 65-Year-Old Woman with an Incorrect Operation on the Left Hand
      Oct 28 33 A 22-Year-Old Woman with Blurred Vision and Renal Failure
      Oct 21 32 A Pregnant Woman with Abdominal Pain and Fluid in the Peritoneal Cavity
      Oct 14 31 A 29-Year-Old Woman with Fever after a Cat Bite
      Sep 30 30 A 15-Year-Old Boy with a Recurrent Skin Lesion
      Sep 23 29 A 29-Year-Old Woman with Fever and Abdominal Pain
      Sep 16 28 A 32-Year-Old Woman, 3 Weeks Post Partum, with Substernal Chest Pain
      Sep 09 27 A 73-Year-Old Woman with Chronic Anemia
      Aug 26 26 A 54-Year-Old Man with Loss of Vision and a Rash
      Aug 19 25 A 24-Year-Old Woman with Abdominal Pain and Shock
      Aug 12 24 A 56-Year-Old Woman with a History of Hodgkin's Lymphoma and Sudden Onset of Dyspnea and Shock
      Jul 29 23 A 49-Year-Old Man with Erythrocytosis, Perinephric Fluid Collections, and Renal Failure
      Jul 22 22 An 87-Year-Old Woman with Dementia and a Seizure
      Jul 15 21 A Request for Retrieval of Oocytes from a 36-Year-Old Woman with Anoxic Brain Injury
      Jul 08 20 A 32-Year-Old Woman with Oligomenorrhea and Infertility
      Jun 24 19 A 35-Year-Old Man with Adenocarcinoma of the Cecum
      Jun 17 18 A 7-Year-Old Boy with Elevated HIV RNA Levels despite Antiretroviral Medications
      Jun 10 17 A 29-Year-Old Woman with Flexion of the Left Hand and Foot and Difficulty Speaking
      May 27 16 A 48-Year-Old Man with a Cough and Pain in the Left Shoulder
      May 20 15 An 85-Year-Old Woman with Mammographically Detected Early Breast Cancer
      May 13 14 A 54-Year-Old Woman with Dizziness and Falls
      Apr 29 13 An 18.5-Month-Old Girl with Watery Diarrhea and Poor Weight Gain
      Apr 22 12 An 89-Year-Old Man with Progressive Dyspnea
      Apr 15 11 A 69-Year-Old Woman with Lethargy, Confusion, and Abnormalities on Brain Imaging
      Apr 08 10 A 37-Year-Old Woman with Weakness and a Mass in the Brain
      Mar 25 9 A 37-Year-Old Woman with Paresthesias and Ataxia
      Mar 18 8 A 22-Year-Old Woman with Hypercalcemia and a Pelvic Mass
      Mar 11 7 A 49-Year-Old Man with Peripheral Neuropathy and Ascites
      Feb 25 6 A 37-Year-Old Man with a Lesion on the Tongue
      Feb 18 5 A 51-Year-Old Man with HIV Infection, Proteinuria, and Edema
      Feb 11 4 A 53-Year-Old Man with Arthralgias, Oral Ulcers, Vision Loss, and Vocal-Cord Paralysis
      Jan 28 3 A 5-Month-Old Boy with Developmental Delay and Irritability
      Jan 21 2 A 47-Year-Old Man with Abdominal and Flank Pain
      Jan 14 1 A 75-Year-Old Man with Hypertension, Hyperglycemia, and Edema

2009 NEJM CPC Cases

      Dec 31 41 A 16-Year-Old Boy with Hypothermia and Frostbite
      Dec 24 40 A 29-Year-Old Man with Fever and Respiratory Failure
      Dec 17 39 A 28-Year-Old Pregnant Woman with Acute Cardiac Failure
      Dec 10 38 A 16-Year-Old Boy with Paroxysmal Headaches and Visual Changes
      Nov 26 37 A 46-Year-Old Woman with Chronic Renal Failure, Leg Swelling, and Skin Changes
      Nov 19 36 A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging
      Nov 12 35 A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes
      Oct 29 34 A 20-Year-Old Man with Sore Throat, Fever, and Rash
      Oct 22 33 A 35-Year-Old Woman with Fever, Abdominal Pain, and Hypotension after Cesarean Section
      Oct 15 32 A 27-Year-Old Man with Progressive Dyspnea
      Oct 08 31 A 26-Year-Old Man with Abdominal Distention and Shock
      Sep 24 30 A 69-Year-Old Man with Recurrent Transitional-Cell Carcinoma of the Ureter.
      Sep 17 29 An 81-Year-Old Man with Weight Loss, Odynophagia and Failure to Thrive
      Sep 10 28 A 68-Year-Old Man with Fatigue, Cough, and Peripheral-Blood Monocytosis
      Aug 27 27 A 56-Year-Old Woman with Fever, Rash, and Lymphadenopathy
      Aug 26 26 A 34-Year-Old Man with Cystic Fibrosis with Abdominal Pain and Distention
      Aug 13 25 A 36-Year-Old Woman with Hormone-Receptor-Positive Breast Cancer
      Jul 30 24 A 26-Year-Old Woman with Painful Swelling of the Neck
      Jul 23 23 A 13-Year-Old Boy with Headache, Nausea, Seizures, and Hypertension
      Jul 16 22 A 59-Year-Old Man with Skin and Pulmonary Lesions after Bone Marrow Transplantation
      Jul 09 21 A 61-Year-Old Woman with Abdominal Pain, Weight Loss, and Renal Failure
      Jun 25 20 A 79-Year-Old Woman with a Blistering Cutaneous Eruption
      Jun 18 19 A 63-Year-Old Woman with Carcinoma of the Gastroesophageal Junction
      Jun 04 18 A 24-Year-Old Woman with Progressive Cough, Dyspnea, and Wasting
      May 28 17 A 30-Year-Old Man with Progressive Neurologic Deficits
      May 21 16 A 32-Year-Old Pregnant Woman with an Abnormal Fetal Ultrasound Study
      May 14 15 A 25-Year-Old Man with Coma after Cardiac Arrest
      Apr 29 14 A 36-Year-Old Man with Chest Pain, Dysphagia, and Pleural and Mediastinal Calcifications
      Apr 23 13 A 54-Year-Old Woman with Respiratory Failure and a Cavitary Lesion in the Lung
      Apr 16 12 A 46-Year-Old Man with Migraine, Aphasia, and Hemiparesis
      Apr 09 11 A 47-Year-Old Man with Fever, Headache, Rash, and Vomiting
      Mar 26 10 A 23-Year-Old Woman with an Abnormal Papanicolaou Smear
      Mar 19 9 An 81-Year-Old Man with Massive Rectal Bleeding
      Mar 12 8 A 36-Year-Old Woman with Headache, Hypertension, and Seizure 2 Weeks Post Partum
      Feb 26 7 A Pregnant Woman with a Large Mass in the Fetal Oral Cavity
      Feb 19 6 A 37-Year-Old Woman with Vertigo, Facial Weakness, and a Generalized Seizure
      Feb 12 5 A 47-Year-Old Woman with a Rash and Numbness and Pain in the Legs
      Jan 29 4 A 39-Year-Old Pregnant Woman with Fever after a Trip to Africa
      Jan 22 3 A 9-Month-Old Boy with Seizures
      Jan 15 2 A 25-Year-Old Man with Pain and Swelling of the Right Hand and Hypotension
      Jan 08 1 A 57-Year-Old Man with Progressive Cognitive Decline

2008 NEJM CPC Cases

2007 NEJM CPC Cases

      Dec 27 40 A 38-Year-Old Man with Weakness in the Hands
      Dec 20 39 A 5-Month-Old Girl with Skin Lesions
      Dec 13 38 A 44-Year-Old Woman with Generalized, Painful, Ulcerated Skin Lesions
      Nov 29 37 A 47-Year-Old Man with Left Ventricular Dysfunction after Heart Transplantation
      Nov 22 36 A 31-Year-Old Woman with Rash, Fever, and Hypotension
      Nov 15 35 A 30-Year-Old Man with Inflammatory Bowel Disease and Recent Onset of Fever and Bloody Diarrhea
      Nov 08 34 A 77-Year-Old Man with Ear Pain,Difficulty Speaking,and Altered Mental Status
      Oct 25 33 A 49-Year-Old HIV-Positive Man with Anemia
      Oct 18 32 A 62-Year-Old Woman With a Second Breast Cancer
      Oct 11 31 A 41-Year-Old Man With Abdominal Pain and Elevated Serum Creatinine
      Sep 27 30 A Newborn Girl with Skin Lesions
      Sep 20 29 A 51-Year-Old Man with Gastric Cancer and Lung Nodules
      Sep 13 28 A 68-Year-Old Man with Syncope
      Aug 30 27 A 30-Year-Old Pregnant Woman with Intrauterine Fetal Death
      Aug 23 26 A 61-Year-Old Man with Recurrent Fevers
      Aug 16 25 A 60-Year-Old Man with Fever, Odynophagia, Weight Loss, and Rash
      Aug 09 24 A 20-Year-Old Pregnant Woman with Altered Mental Status
      Jul 26 23 A 9-Year-Old Boy with Bone Pain, Rash, and Gingival Hypertrophy
      Jul 19 22 A Woman with a Family History of Gastric and Breast Cancer
      Jul 12 21 A 58-Year-Old Woman with Headaches, Weakness, and Strokelike Episodes
      Jun 28 20 An 11-Year-Old Boy with a Calcified Mass in the Nose
      Jun 19 19 A 19-Year-Old College Student with Fever and Joint Pain
      Jun 14 18 A 54-Year-Old Man with Early-Stage Prostate Cancer
      May 31 17 A 25-Year-Old Woman with Relapsing Fevers and Recent Onset of Dyspnea
      May 24 16 A 61-Year-Old Man with a Mediastinal Mass
      May 17 15 A 20-Year-Old Woman with Asthma and Cardiorespiratory Arrest
      May 10 14 A 59-Year-Old Man with Fever and Pain and Swelling of Both Eyes and the Right Ear
      Apr 26 13 A 46-Year-Old Woman with Gynecologic and Intestinal Cancers
      Apr 19 12 A 56-Year-Old Woman with Renal Failure after Heart-Lung Transplantation
      Apr 12 11 A 59-Year-Old Man with Neck Pain, Weakness in the Arms, and Cranial-Nerve Palsies
      Mar 29 10 A 55-Year-Old Man Impaled in a Rowing Accident
      Mar 22 09 A 27-Year-Old Woman with Pain and Swelling of the Legs
      Mar 15 08 A 48-Year-Old Man with Chest Pain Followed by Cardiac Arrest
      Mar 08 07 A 59-Year-Old Woman with Diabetic Renal Disease and Nonhealing Skin Ulcer
      Feb 22 06 A 28-Year-Old Man with a Mass in the Testis
      Feb 15 05 A 53-Year-Old Man with a Prosthetic Aortic Valve and Recent Onset of Fatigue, Dyspnea, Weight Loss, and Sweats
      Feb 08 04 A 56-Year-Old Woman with Rapidly Progressive Vertigo and Ataxia
      Jan 25 03 A 3-Year-Old Boy with Recurrent Episodes of Respiratory Insufficiency
      Jan 18 02 A 49-Year-Old Woman with a Pigmented Lesion on the Arm
      Jan 11 01 A 40-Year-Old Woman with Epistaxis, Hematemesis, and Altered Mental Status

2006 NEJM CPC Cases

      Dec 28 40 A 64-Year-Old Man with Anemia and a Low Level of HDL Cholesterol
      Dec 21 39 A 24-Year-Old Woman with Systemic Lupus Erythematosus, Seizures, and Right Arm Weakness
      Dec 14 38 A 5-Year-Old Boy with Headache and Abdominal Pain
      Nov 30 37 A 19-Year-Old Woman with Thyroid Cancer and Lower Gastrointestinal Bleeding
      Nov 23 36 A 35-Year-Old Pregnant Woman with New Hypertension
      Nov 16 35 A Newborn Boy with Hypotonia
      Nov 09 34 A 72-Year-Old Woman with Nausea Followed by Hypotension and Respiratory Failure
      Oct 26 33 A 43-Year-Old Man with Diabetes, Hypogonadism, Cirrhosis, Arthralgias, and Fatigue
      Oct 19 32 A 3-Year-Old Girl with Fever after a Visit to Africa
      Oct 12 31 A 15-Year-Old Girl with Severe Obesity
      Sep 28 30 A 41-Year-Old Man with Dyspnea, Fever, and Lymphadenopathy
      Sep 21 29 A 43-Year-Old Woman with Painful Nodules on the Fingertips, Shortness of Breath and Fatigue
      Sep 14 28 A 59-Year-Old Man with Masses in Both Kidneys
      Aug 31 27 A 17-Year-Old Boy with Fever and Lesions in the Liver and Spleen
      Aug 24 26 A 19-Year-Old Woman with Difficulty Walking
      Aug 17 25 A 41-Year-Old Woman with Painful Subcutaneous Nodules
      Aug 10 24 A 40-Year-Old Woman with Hypotension after an Overdose of Amlodipine
      Jul 27 23 A 36-Year-Old Man with Numbness in the Right Hand and Hypertension
      Jul 20 22 A 77-Year-Old Man with a Rapidly Progressive Gait Disorder
      Jul 13 21 A 61-Year-Old Man with Left-Sided Facial Pain
      Jun 30 20 An 84-Year-Old Man with Staphylococcal Bacteremia and Renal Failure
      Jun 22 19 A 22-Month-Old Boy with the Rapid Growth of Subcutaneous Nodules
      Jun 15 18 A 57-Year-Old Woman with Numbness and Weakness of the Feet and Legs
      Jun 08 17 A 34-Year-Old Man with Cavitary Lung Lesions
      May 25 16 A 72-Year-Old Woman Admitted to the Emergency Department because of a Sudden Change in Mental Status
      May 18 15 A 46-Year-Old Woman With Sudden Onset Of Abdominal Distention
      May 11 14 A 25-Year-Old Woman With Anemia And Iron Overload
      Apr 27 13 A 50-Year-Old Man With A Painful Bone Mass And Lesions In The Liver
      Apr 20 12 A 37-Year-Old Man With Hemoptysis And A Pulmonary Infiltrate
      Apr 13 11 A 54-Year-Old Woman With A Mass In The Pelvis
      Mar 30 10 A 66-Year-Old Woman With Barrett's Esophagus With High-Grade Dysplasia
      Mar 23 9 A 35-Year-Old Woman With Recurrent Right-Upper-Quadrant Pain
      Mar 16 8 A 71-Year-Old Woman With Crohn's Disease And Altered Mental Status
      Mar 09 7 A 47-Year-Old Man With Altered Mental Status And Acute Renal Failure
      Feb 23 6 A 71-Year-Old Woman With Urinary Incontinence And A Mass In The Bladder
      Feb 16 5 An 11-Year-Old Girl With Loss Of Vision In The Right Eye
      Feb 09 4 A 79-Year-Old Woman With Myalgias, Fatigue, And Shortness Of Breath
      Jan 26 3 A 63-Year-Old Woman With Jaundice And A Pancreatic Mass
      Jan 19 2 A 31-Year-Old, HIV-Positive Man With Rectal Pain
      Jan 12 1 A 64-Year-Old Male Lung-Transplant Recipient With Fever, Cough, Hemoptysis, And Abdominal Pain

2005 NEJM CPC Cases